The Environmental Protection Agency (EPA) is officially reviewing five highly toxic plastic chemicals, focusing on vinyl chloride, known for its toxicity and involvement in the East Palestine, Ohio, train wreck fire. The review could lead to stringent regulations or bans. Vinyl chloride, used in PVC production, is carcinogenic and neurotoxic. Despite longstanding awareness, industrial opposition has hindered regulatory efforts. This review follows an incident highlighting the dangers of transporting the chemical. The EPA's process will include public and industry input under the Toxic Substances Control Act and may take years to conclude, facing potential political and industrial resistance.