A recent study in BME Frontiers introduces Qx-D, a dual-functional bone regeneration scaffold with promising applications for treating infected bone defects. By integrating a macromolecular quaternary ammonium salt into a demineralized bone matrix, researchers created a scaffold exhibiting 99.9% antibacterial efficiency against various bacteria, including MRSA and E. coli. Qx-D supports bone marrow stromal cells' adhesion and differentiation while promoting osteogenic differentiation, demonstrated by in vivo studies showing reduced inflammation and enhanced bone regeneration in a rat model. This innovation could improve management and surgical outcomes for bone infections without relying on antibiotics, which are prone to resistance.